Last edited by Nashura
Saturday, July 25, 2020 | History

8 edition of Quasispecies and RNA Virus Evolution found in the catalog.

Quasispecies and RNA Virus Evolution

Principles and Consequences (Molecular Biology Intelligence Unit)

by Esteban Domingo

  • 216 Want to read
  • 17 Currently reading

Published by Landes Bioscience .
Written in English

    Subjects:
  • Genetics,
  • Medical / Nursing,
  • Science/Mathematics

  • The Physical Object
    FormatPaperback
    Number of Pages173
    ID Numbers
    Open LibraryOL12320541M
    ISBN 101587060779
    ISBN 109781587060779
    OCLC/WorldCa50418792

    RNA viruses exist in a mutation-selection balance where a genetically diverse population of variant genomes are ordered around the fittest genome from a single progenitor, known as the quasispecies concept, and this is important in the evolution of RNA viruses. The quasispecies as a model of RNA virus evolution. The remarkable mutational power of RNA viruses has meant that their evolution has often been considered to .

      A large number of medically important viruses, including HIV, hepatitis C virus, and influenza, have RNA genomes. These viruses replicate with extremely high mutation rates and exhibit significant genetic diversity. This diversity allows a viral population to rapidly adapt to dynamic environments and evolve resistance to vaccines and antiviral drugs. For the last 30 years, quasispecies . In addition to explaining what is currently known about the origins of RNA viruses, the book describes the mechanisms of RNA virus evolution, RNA virus quasispecies, and comparative genomics, as well as interesting new concepts, such as phylogeography.

    Evolution of RNA viruses occurs through disequilibria of collections of closely related mutant spectra or mutant clouds termed viral quasispecies. Here we review the origin of the quasispecies concept and some biological implications of quasispecies dynamics. Two main aspects are addressed: (i) muta . Quasispecies as a theoretical concept was first developed by Eigen and his colleagues (Eigen and Schuster ) and shown to be an adequate descriptor of RNA viruses at the molecular level (reviews in Domingo et al. , Holland ; historical account in Domingo et al. ).


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Quasispecies and RNA Virus Evolution by Esteban Domingo Download PDF EPUB FB2

Quasispecies and RNA Virus Evolution: Principles and Consequences (Molecular Biology Intelligence Unit) 1st Edition by Esteban Domingo (Author), John J.

Holland (Author), Christof K. Biebricher (Author) & 0 more5/5(1). Quasispecies and RNA Virus Evolution: Principles and Consequences (Molecular Biology Intelligence, Unit 14) 1st Edition by Esteban Domingo (Author)5/5(1).

Quasispecies and RNA Virus Evolution by Domingo, Esteban (ebook) Quasispecies and RNA Quasispecies and RNA Virus Evolution book Evolution: Principles and Consequences by Esteban Domingo. RNA viruses, by virtue of their high mutation rates and large population sizes, from complex mutant distributions termed viral quasispecies.

Abstract. This chapter discusses the high mutation frequencies and rapid evolution potential of RNA viruses. The concepts discussed are applicable to all “ordinary” RNA viruses (riboviruses), viroids and satellite RNAs; to retroviruses; and to viruses (such as the hepadnaviruses) with DNA genomes which replicate via RNA by:   RNA viruses form complex distributions of closely related but nonidentical genomes that are subjected to a continuous process of genetic variation, competition, and selection (Fig.

1).These so-called viral quasispecies have been described in vivo through the analysis of molecular and biological clones isolated from viral populations, and more recently using ultradeep sequencing by: 3. Viral quasispecies evolution refers to the fact that RNA viral populations consist of mutant spectra (or mutant clouds) rather than genomes with the same nucleotide sequence.

Mutant spectra and not individual genomes are the target of evolutionary by: ABSTRACT. The comparative analysis of genes and genomes is frequently used to reveal the patterns and processes of RNA virus evolution. Herein, I review some of the various computational (in silico) methods that comprise this approach and outline their multi-faceted contributions to understanding evolutionary change in RNA viruses.I focus on five areas where the most important developments.

Quasispecies and Population Genetics Theories of the Evolution of RNA Viruses. There is abundant theoretical literature related to the dynamics of populations in which mutation is a.

Viruses traditionally have been marginalized from evolutionary biology, as noted in one of the first sentences of The Evolution and Emergence of RNA uently, a central goal of Edward Holmes' (Center for Infectious Disease Dynamics, Pennsylvania State University) book is to show that they are as valuable a system to study evolutionary processes as are other model systems.

Holmes and Moya claim that quasispecies is an unnecessary and misleading description of RNA virus evolution, that virologists refer to quasispecies inappropriately, and that there is little evidence of quasispecies in RNA virus evolution.

They wish to look for other ideas in evolutionary biology and to set down an agenda for future by: In addition to explaining what is currently known about the origins of RNA viruses, the book describes the mechanisms of RNA virus evolution, RNA virus quasispecies, and comparative genomics, as well as interesting new concepts, such as phylogeography.

This term refers to the spatial movement of a phylogenetic species, which can be described in. In order to generate stable vaccine strains, the evolution of these viruses must be properly understood. This review is centered on the examination of the evidence for the heterogeneous nature of RNA genomes (quasispecies), the factors leading to quasispecies formation and its implications on virulence.

Quasispecies and RNA Virus Evolution by Esteban Domingo,available at Book Depository with free delivery : Esteban Domingo. concepts in RNA virus evolution. FASEB J. 10, () Key Words: genetic bottleneck. Red Queen hypolhesis ‘popula-lionequilibrium quasispecies-competitive exclusion principle-RNA genome replication VIRUSES WITH AN RNA genome, or viruses that use RNA as a replicative intermediate, are the most abundant group of subcellular parasites.

Impact of RNA Virus Evolution on Quasispecies Formation and Virulence Article (PDF Available) in International Journal of Molecular Sciences 20(18) September with Reads. Multiplication strategies of RNA genetic elements --Molecular recognition and replication enzymes --Quantitative molecular evolution --Darwinian evolution of RNA in vitro --Experimental studies on viral quasispecies --Population dynamics and virus adaptability --Connections, implications and prospects.

Viral quasispecies evolution refers to the fact that RNA viral populations consist of mutant spectra (or mutant clouds) rather than genomes with the same nucleotide sequence.

Mutant spectra and not individual genomes are the target of evolutionary events. Domingo E, Sheldon J, Perales C. Viral quasispecies evolution. Microbiol Mol Biol Rev.

; 76 (2)– [PMC free article] Duarte EA, Novella IS, Ledesma S, Clarke DK, Moya A, et al. Subclonal components of consensus fitness in an RNA virus clone. The concept of quasispecies is fundamental to the understanding of virus variation and evolution; it is discussed in detail by Eigen (), Domingo (), Smith et al.

(), and Domingo et al. The term quasispecies describes a type of population structure in which collections of closely related genomes are subjected to a continuous process of genetic variation, competition, and selection. High mutation rates and quasispecies were verified for other RNA viruses based on dissection of viral populations by molecular or biological cloning, and sequence analysis of individual clones.

John Holland and colleagues were the first to recognize that a rapidly evolving RNA world inserted in a DNA-based biosphere had multiple evolutionary and medical implications.

The phenomenon of quasispecies within a viral population is also discussed to reflect virulence and its implications for RNA viruses.Virus as Composition, Complexity, Quasispecies, Dynamics, and Biological Implications, Second Edition, explains the fundamental concepts surrounding viruses as complex populations during replication in infected ental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, and the probability to be transmitted or respond to.

The term quasispecies was adopted from a theory of the origin of life in which primitive replicons) consisted of mutant distributions, as found experimentally with present day RNA viruses. The theory provided a new definition of wild type, and a conceptual framework for the interpretation of the adaptive potential of RNA viruses that contrasted with classical studies based on consensus sequences.